慢性淋巴细胞白血病的全球负担 从1990年到2021年
Chen Chen1, Ling Wang1, Shenghong Du1
1Department of Hematology, Tai'an City Central Hospital of Qingdao University, Tai'an, China.
Cancer control : journal of the Moffitt Cancer Center
|November 12, 2025
概括
全球慢性淋巴细胞白血病 (CLL) 负担下降,但患病率上升. 区域差异仍然存在,东亚地区的病例显著增加,突显了针对性公共卫生战略的必要性.
科学领域:
- 血液学 血液学 血液学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 慢性淋巴细胞白血病 (CLL) 是一个日益严重的公共卫生问题.
- 了解CLL负担的时间趋势对于有效的卫生政策至关重要.
- 2021年全球疾病负担数据为流行病学分析提供了全面的资源.
研究的目的:
- 从1990年到2021年分析慢性淋巴细胞白血病 (CLL) 发病率,患病率,死亡率和残疾调整寿命年 (DALYs) 的全球和区域趋势.
- 研究CLL负担与社会经济发展之间的关系.
- 确定导致CLL负担的主要风险因素.
主要方法:
- 利用2021年全球疾病负担数据进行分析.
- 计算的发病率,流行率,死亡率,DALY,年龄标准化率 (ASR),百分比变化和估计年百分比变化 (EAPC).
- 采用达斯古普塔的趋势分析和边界分析方法来评估CLL负担与社会发展之间的联系.
主要成果:
- 全球CLL发病率,死亡率和DALYs下降,而患病率上升.
- 具有高社会发展指数 (SDI) 的地区呈现下降趋势,而其他SDI地区呈现上升趋势.
- 在东亚观察到显著的患病率增加;男性的发病率和死亡率始终较高. 吸烟,高BMI和职业暴露 (,甲) 被确定为关键风险因素.
结论:
- 慢性淋巴细胞白血病 (CLL) 的全球总体负担已经下降.
- 严重的CLL负担的区域差异仍然存在,需要量身定制的公共卫生干预措施.
- 持续监测和有针对性的战略对于应对不断变化的CLL环境至关重要.
相关概念视频
Disorders of Leukocytes
1.8K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.8K
Primary Lymphoid Organs
14.5K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
14.5K
Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
Secondary Lymphoid Organs
8.7K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.7K
Prevalence and Incidence
1.4K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.4K


