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Updated: Jan 11, 2026

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通过DNABERT和表观遗传特征改善了CRISPR/Cas9的目标外预测

Kai Kimata1, Kenji Satou2

  • 1Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan.

PloS one
|November 12, 2025
PubMed
概括

预测CRISPR/Cas9的脱效应对于安全的基因组编辑至关重要. 一个新的模型,DNABERT-Epi,使用基因组预训练和表观遗传数据来显著提高预测准确度.

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