可吞的可扩展纤维囊用于食道细胞的非内镜取样
S M Shatil Shahriar1,2, Huy Quang Tran1, Farzad Hayati1
1Department of Surgery - Transplant and Mary and Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Science advances
|November 12, 2025
概括
一个新的可吞囊非侵入性地收集食道细胞,有助于早期检测食道腺癌. 这种低成本的技术可以通过在初级保健机构进行广泛的查来提高生存率.
科学领域:
- 胃肠病学 胃肠病学
- 生物材料科学 生物材料科学
- 医疗器械 医疗器械
背景情况:
- 食道腺癌的预后不好,五年生存率约为18.8%.
- 晚期诊断很常见,因为缺乏有效的全民查.
- 巴雷特食道,前体病变,在食道腺癌诊断之前,通常是未被诊断出来的.
研究的目的:
- 开发一种新型的可吞囊,用于非创伤性食道上皮细胞检索.
- 为了实现非侵入性,无镇静的食道采样,以潜在的早期癌症检测.
- 创建一个低成本,高吞吐量平台,用于食道采样在不同的医疗机构.
主要方法:
- 使用气泡纳米纤维或混合气凝制造可吞囊.
- 在胃液暴露引起的in situ囊再扩张.
- 扩展囊的绳索绑定检索用于细胞样本采集.
- 在猪模型中评估囊溶解,再膨胀时间,取回力和组织捕获.
主要成果:
- 囊在暴露胃液后,在几秒钟内迅速重新扩张.
- 溶解发生在2分钟内,确保安全通行.
- 需要最小的提取力来提取囊.
- 完整的食道上皮层始终被捕获而不会造成伤害.
结论:
- 可吞囊平台为食道细胞采样提供了一种安全,无创和高效的方法.
- 这项技术有可能促进食道疾病的早期诊断,包括癌症.
- 囊的低成本和高通量性质使其适用于初级保健和资源有限的环境.
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