延迟神经后续的风险因素和结果分析,在一氧化碳中毒的老年患者中
Yuehong Ma1,2, Wenying Lv3, Huijun Hu2
1Department of Hyperbaric Oxygen, School of Medicine, South China University of Technology, Guangzhou, 510006, China.
概括
老年人一氧化碳 (CO) 中毒可能导致神经问题. 较低的初始GCS得分和更长的昏迷时间是老年人神经系统延迟后果的危险因素.
科学领域:
- 神经学 神经学
- 毒理学 毒理学 毒理学
- 老年病的医生 老年病的医生
背景情况:
- 一氧化碳 (CO) 中毒是中毒的常见原因之一,可能会导致神经系统的后果.
- 老年人群特别容易受到伤害,但在CO中毒研究中未得到充分研究.
研究的目的:
- 调查老年患者 (65岁或以上) 中CO中毒的风险因素和结果.
- 在这个人口群体中确定延迟神经连续 (DNS) 和长期神经连续 (LNS) 的预测因子.
主要方法:
- 对167名因非火灾,非自杀事故造成的CO中毒的老年患者的回顾性审查 (2013-2023年).
- 分析临床数据,症状,成像发现和治疗结果.
- 多变量分析以确定DNS和LNS的独立风险因素.
主要成果:
- 煤炭加热是主要暴露源 (90%).
- 52%的患者出现了延迟的神经连续 (DNS),78%的患者进展为长期连续 (LNS).
- 最初的格拉斯哥昏迷量表 (GCS) 评分和昏迷持续时间是DNS的独立风险因素 (p<0.001). 昏迷持续时间也是LNS的危险因素 (p<0.001).
- 高压氧气 (HBO2) 治疗对DNS或LNS没有显著的益处或危害.
结论:
- 最初的GCS得分和昏迷时间是老年CO中毒患者DNS的重要风险因素.
- 昏迷的持续时间是预后差和LNS的一个关键因素.
- 老年患者需要密切监测和随访,特别是那些长期昏迷和初始低GCS分数的患者.
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