合成大麻素:对生物样品制备方面的挑战和进展进行了批判性审查
Luisa Raspini E Silva1, Bruna Espíndola da Silva1, Carolina Henkes Inamassu1
1Program on Pharmacology, Federal University of Santa Catarina, Brazil.
Journal of chromatography. A
|November 12, 2025
概括
合成大麻素 (SCs) 的法医分析面临着由于其多样性和快速出现的挑战. 本综述详细介绍了生物样本中SCs检测的进展和障碍.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 合成大麻素 (SCs) 是新型精神活性物质 (NPS) 的最大类别.
- 它们的巨大化学多样性,复杂的新陈代谢和低度构成了重大分析挑战.
- 新型SCs的快速出现使法医能力受到压力.
研究的目的:
- 审查最近在生物样本中分析合成大麻素的进展和挑战.
- 确定文献中的差距,并探索SCs检测的未来方向.
- 评估绿色和白色分析化学原理在SCs分析中的应用.
主要方法:
- 对2018年1月至2025年8月间发表的33篇文章进行范围审查.
- 数据表化,总结和分析SC特征和样本类型的数据.
- 检查样品制备方案,色谱技术和参考标准的挑战.
主要成果:
- 对SCs群体和生物样本实用性的分析揭示了文献上的空白.
- 讨论了与SC及其代谢物参考标准相关的挑战.
- 评估了既定和新兴的分析方法,包括GAC和WAC原则.
结论:
- 合成大麻素的分析需要不断调整法医方法.
- 用参考标准应对挑战,采用更绿色的分析方法至关重要.
- 未来的研究应该专注于新兴趋势和新的SCs检测策略.
相关概念视频
Sample Preparation for Analysis: Overview
2.3K
Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...
2.3K
Sample Preparation for Analysis: Advanced Techniques
1.2K
Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.2K


