在患有慢性肠道病变的狗中,重复的便微生物群移植可以降低疾病活性和皮质类固醇使用
Linda Toresson1,2, Ulrika Ludvigsson2, Gunilla Olmedal2
11Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX.
Journal of the American Veterinary Medical Association
|November 12, 2025
概括
重复的便微生物群移植 (FMT) 有效地治疗了狗的慢性肠道病变 (CE),特别是那些患有轻度失生症的狗. 这种方法减少了耐药病例中的疾病活性和皮质类固醇依赖.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 狗的慢性肠道病变 (CE) 是一种具有挑战性的疾病,通常需要先进的治疗策略.
- 耐火性CE病例呈现出对新型治疗选择的显著临床需求.
- 便微生物种移植 (FMT) 正成为通过调节肠道微生物组来治疗胃肠道疾病的潜在治疗方法.
研究的目的:
- 评估重复便微生物群移植 (FMT) 作为耐火性慢性肠道病变 (CE) 的狗的辅助治疗的疗效.
- 评估临床结果和便参数,包括失生症指数,胆酸和calprotectin,在FMT之后.
- 为了确定反复 FMT 响应的预测因子,在具有 CE 的狗中.
主要方法:
- 一项前性的纵向观察研究,涉及39只耐火CE.狗.
- 狗在一个月内接受了2到3次直肠FMT.
- 在6个月的时间里,使用犬炎性肠病活动指数 (CIBDAI) 和便分析进行了临床评估.
主要成果:
- 39只狗中有28只 (71.8%) 对FMT有反应,其中13只狗的皮质类固醇水平逐渐降低.
- 与非响应者相比,长期响应者 (LLRs) 的基线失生症指数明显较低,二次未结合便胆酸的百分比较高.
- 在FMT后的LLR中,dysbiosis指数显著下降,而该组的临床改善持续了6个月.
结论:
- 重复的FMT作为一种有效的辅助治疗耐火性CE在狗,特别是那些微小或中度的dysbiosis.
- 预先存在的明显失调和胆酸代谢不良可能与对FMT的反应不佳或短暂相关.
- 对于没有反应的病例,需要对优化FMT协议进行进一步的调查,可能包括重复管理.
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