通过人工智能驱动的药物递送技术,朝着道后生物精密疗法迈进
Puccetti Matteo1, Pariano Marilena2, Wojtylo Paulina Anna1
1Department of Pharmaceutical Science, University of Perugia, Perugia 06132, Italy.
Current opinion in immunology
|November 12, 2025
概括
像英多尔这样的后生物因其多样化的生物活性而显示出对宿主健康的治疗潜力. 临床翻译的挑战需要新的方法,如人工智能,用于未来的发展.
科学领域:
- 微生物组研究的研究.
- 后生物学的后生物学.
- 主体-微生物相互作用
背景情况:
- 印及其衍生物是通过细菌的托代谢产生的后生物.
- 这些化合物在各种生物社区中普遍存在.
- 它们在宿主生理学和宿主/微生物界面的稳态中发挥作用.
研究的目的:
- 审查印及其衍生物的生物活性.
- 确定阻碍其临床翻译的挑战.
- 提出人工智能作为未来发展的工具.
主要方法:
- 关于英多尔生物活性的文献综述.
- 对药物动力学和配方挑战的分析.
- 在药物开发中探索人工智能应用.
主要成果:
- 印醇衍生物具有抗氧化,抗炎,抗糖尿病,抗高血压,免疫调节和代谢作用.
- 主要挑战包括药物动力学限制,结构性乱交和配方困难.
- 人工智能为克服这些翻译障碍提供了一个框架.
结论:
- 印及其衍生物代表了从微生物组中获得的有前途的治疗剂.
- 解决翻译挑战对于它们的临床应用至关重要.
- 人工智能可以加速这些后生物的开发,用于治疗.
相关概念视频
01:16Drug Delivery: Overview
708
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
708
01:29Drug Delivery: Parenteral Route
1.5K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.5K
01:18Drug Delivery: Enteral Route
1.5K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.5K
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
186
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
186
01:22Drug Delivery: Miscellaneous Routes
699
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
699
01:29Microorganisms in Medicine and Therapeutics
922
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
922