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作为多发性硬化症患者平衡的衡量标准,稳定性的常态边际

Olivia F Simpson¹, Dimitar Stanev², Joe Pitt-Francis³

¹Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, Oxfordshire, UK; Department of Computer Science, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, Oxfordshire, UK.

Clinical biomechanics (Bristol, Avon)

|November 12, 2025

概括

全球稳定边际 (MoS) 的范围与多发性硬化症 (MS) 中的平衡障碍相关. 这项测量有效量化了不同立场的余额赤字,并提供了作为临床评估工具的潜力.

科学领域:

生物力学生物力学
神经学神经学
临床评估临床评估

背景情况:

多发性硬化症 (MS) 是一种自身免疫性中枢神经系统疾病,影响着姿势控制.
稳定性边际 (MoS) 衡量接近失衡的情况.
在MS (PwMS) 患者中,站立的MoS比走路的MoS少受研究.

研究的目的:

探索PwMS中常设的MoS和临床措施之间的关系.
确定一个常规的MoS特征,量化MS相关的余额损失.
评估不同立场的现有MoS.

主要方法:

一项涉及96名PwMS的观察性研究.
参与者站在五种姿势中,每个姿势30秒.
使用移动捕捉计算并与临床尺度 (EDSS,ABC,MSWS-12) 进行比较的常态MoS.

主要成果:

全球常态MS的范围和标准偏差与MS损伤 (EDSS) 在各个立场之间有显著的相关性.
常态MoS与患者报告的结果相关 (ABC,MSWS-12).
全球MS的范围显示在区分MS严重程度水平方面具有很强的有效性.

结论:

常规的MS,特别是全球MS的范围,与已建立的临床MS尺度有很强的相关性.
全球MoS的范围是建议在PwMS中进行常设的MoS研究.
常设的MS显示出作为MS平衡障碍的临床结果衡量的潜力.

关键词:

在EDSS中使用EDSS.稳定性边际稳定性的边际动作捕捉运动捕捉多发性硬化症是多发性硬化症.静态平衡静态平衡静态平衡

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