新型益生菌联盟在超脂血性大鼠中维持骨肌肉功能
Sai Kumar Somashekher1, Pallavi Ratha2, Manasa Hassan Yashwanthkumar2
1Department Of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, 570020, Karnataka, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, Uttar Pradesh, India.
Biochemical and biophysical research communications
|November 12, 2025
概括
这项研究表明,一种新的益生菌混合物有效地防止过脂性大鼠的肌肉功能丧失. 益生菌通过减少缩标志物和增强肌体调节剂来改善肌肉力量,耐力和完整性.
科学领域:
- 生物化学 生物化学
- 生理学 生理学 生理学
- 微生物学 微生物学
背景情况:
- 超脂血症与肌肉功能障碍和缩有关.
- 益生菌在调节新陈代谢和炎症过程方面显示出潜力.
- 了解益生菌对代谢障碍肌肉健康的影响至关重要.
研究的目的:
- 评估一种新型益生菌联盟在预防超脂血症诱导的肌肉功能障碍方面在老鼠模型中的有效性.
- 研究益生菌对肌肉完整性和功能的保护作用背后的分子机制.
主要方法:
- 雄性Wistar大鼠被食高脂肪饮食以诱导超脂血症.
- 这些组接受了安慰剂,奥利斯塔特和胆固醇胺,或益生菌联盟 (Lactobacillus acidophilus,Bacillus coagulans,Streptococcus thermophilus).
- 肌肉功能,完整性标志物,缩和肌原性调节剂在90天后被评估.
主要成果:
- 益生菌显著降低了体重增加,内脏脂肪和脂肪与肌肉的比率.
- 益生菌治疗改善了肌肉功能参数,包括力量,耐力和协调.
- 益生菌通过降低损伤标志物和降低缩标志物 (Atrogin-1, MuRF1, FoXO1) 的调节肌肉完整性,同时上调肌体调节剂 (MyoD, MyoG).
结论:
- 一个新的益生菌联盟有效地维持了高脂血症大鼠的肌肉功能和完整性.
- 益生菌提供了一个潜在的治疗策略,用于管理与代谢障碍有关的肌肉并发症.
- 需要进一步的研究来探索这些益生菌在人类健康中的临床应用.
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