中年和晚年心血管健康指标和生物衰老标记的变化;一个多队列研究
Nigus Gebremedhin Asefa1, Yi-Han Hu1, Zhiguang Li1
1Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD, USA.
EBioMedicine
|November 12, 2025
概括
吸烟和高BMI等心血管风险因素加速生物衰老. 修改这些因素,包括体力活动和饮食,可能会减缓衰老并降低成人疾病风险.
科学领域:
- 表观遗传学和衰老研究研究.
- 心血管健康研究 心血管健康研究
- 纵向队列分析 纵向队列分析
背景情况:
- 心血管 (CV) 风险因素可能会影响生物衰老 (BA) 速度.
- 生命早期的因素可能会影响DNA甲基化 (DNAm),影响长期的关联.
- 这项研究调查了心血管风险因素与中年和老年人衰老速度变化的相关性.
研究的目的:
- 检查心血管风险因素与生物衰老的速度之间的关系.
- 为了确定可修改的心血管风险因素是否与加快或减缓衰老有关.
- 分析随着时间的推移与心血管健康相关的衰老速度的变化.
主要方法:
- 分析了来自三个群体 (AGES-RS,CARDIA,InCHIANTI) 的4848名参与者的DNA甲基化数据.
- 使用DunedinPACE (DDPACE) 测量衰老的速度.
- 评估心血管风险因素,包括吸烟,BMI,血压,葡萄糖和体力活动 (PA).
主要成果:
- 吸烟,更高的BMI和血糖在5年内与更快的衰老 (更高的DDPACE) 纵向相关.
- 身体活动和更健康的饮食分数与缓慢衰老有关.
- 更高的包装年,BMI,SBP和DBP增加了成为衰老"加速器"的可能性.
结论:
- 可修改的心血管风险因素,特别是吸烟,不活动和心脏代谢健康不佳,与加速的生物衰老有关.
- 针对这些因素可能会减缓衰老,降低与年龄相关的疾病负担.
- 专注于心血管健康的干预措施可能会影响中年和老年人群的健康衰老.
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