哈森的标志在疹中 Zoster Ophthalmicus:一个系统的审查和元分析
Andrew Mihalache1, Philip Yu2, Brendan K Tao3
1Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Ophthalmology
|November 12, 2025
概括
哈森征兆 (HS) 预测疹眼科 (HZO) 的眼部并发症,但它的缺席并不排除它们. 这一系统性审查证实HS是风险分层HZO患者的宝贵工具.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 皮肤病学 皮肤病学
背景情况:
- 哈森征兆 (HS),表明鼻神经受影响,传统上与疹眼科 (HZO) 有关.
- 最近的辩论质疑HS对HZO眼部并发症的预测价值.
- 临床医生使用HS进行风险分层,但其临床实用性尚不确定.
研究的目的:
- 系统地审查和元分析HS与眼部参与HZO之间的关联.
- 评估HS对眼部并发症的预测意义.
- 评估HS在HZO患者的诊断性能.
主要方法:
- 观察性研究的系统审查和元分析.
- 在Ovid MEDLINE,Embase和Cochrane图书馆搜索到2025年3月.
- 评估偏差风险并计算聚合赔率比率,灵敏度,特异性,PPV和NPV.
主要成果:
- 包括14项研究 (1969名患者).
- HS与明显增加眼部参与的几率相关 (OR = 6.51,P < 0.01).
- HS显示高特异性 (89.2%) 和PPV (88.5%),但中度敏感性 (52.6%) 和NPV (59.8%).
结论:
- 低确定性证据支持HS作为HZO眼部参与的预测因素.
- HS的高特异性和PPV有助于临床风险分层.
- 缺少HS并不可靠地排除眼部并发症.
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