在抑郁症中无意识地提高了自下而上的处理:通过EEG和fMRI动态因果建模的见解
Julia Schräder1, Thilo Kellermann2, Damin Kühn3
1Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen, Aachen, Germany; JARA-Translational Brain Medicine, Aachen, Germany; Center for Computational Life Science, RWTH Aachen University, Germany.
Journal of affective disorders
|November 12, 2025
概括
大型抑郁症 (MDD) 患者与健康对照人群相比,表现出明显的神经处理差异. EEG捕获了早期的自下而上的处理,而fMRI显示了MDD中自上而下的调节受损,影响了情绪处理.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 同时的脑电图 (EEG) 和功能磁共振成像 (fMRI) 为神经信号提供高时间和空间分辨率.
- 大型抑郁症 (MDD) 与前肢边缘情绪调节的改变有关.
- 了解这些变化对于开发有效治疗方法至关重要.
研究的目的:
- 调查MDD患者和健康对照 (HC) 之间神经处理和功能连接的差异.
- 区分EEG和fMRI在捕捉自下而上的和自上而下的神经生理网络中的作用.
- 探索无意识和有意识的情绪处理中与刺激相关的变化.
主要方法:
- 60名MDD患者和66名HC患者在情绪化面部表情的启动任务期间同时接受了EEG-fMRI.
- 动态因果建模 (DCM) 分析了皮层 (背侧前额叶皮层,状环) 和皮层下 (杏仁体) 区域之间的有效连接.
- 模型评估了自下而上和自上而下神经生理网络的刺激相关变化,用于有意识和无意识的处理.
主要成果:
- 贝叶斯模型选择有利于EEG-DCM的自下而上的处理模型,无论是群体还是条件.
- fMRI-DCM显示HC的混合自上而下/自下而上模型,但主要是MDD的自下而上模型.
- 杏仁体活动影响背侧前额皮层 (DLPFC) 活动不同于意识和无意识条件在两个组.
结论:
- 脑电图数据主要捕捉早期,快速,自下而上的处理,而fMRI反映了自下而上的和自上而下的调节.
- 在早期处理中通过自下而上的连接减少DLPFC活动可能会损害MDD中自上而下的情绪调节.
- 这些发现突出了MDD中独特的神经处理特征以及EEG和fMRI的互补作用.
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