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Updated: Jan 11, 2026

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β-catenin/TCF4/NANOG轴控制着结直肠癌细胞中的miR-302转录

Kiarash Saleki1, Miao Xue2, Amirreza Mazloomi3

  • 1Cancer Genetics & Stem Cell Group, The BioDiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK; Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Gene
|November 12, 2025
PubMed
概括

miR-302集群激活NANOG,而Wnt/β-catenin信号传递和NANOG在结直肠癌 (CRC) 干细胞中促进miR-302,揭示了一个反循环. 这为CRC揭示了新的治疗点.

关键词:
癌症类似干细胞的细胞.结肠直肠癌是一种癌症.这是一个NANOGNANOG.没有编码的RNA.TCF4CF4是什么意思转录法规 转录法规在Wnt/β-catenin中使用.在 miR-302 集群中.

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