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Updated: Jan 11, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

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通过调节FOXA1染色体结合的调和活动,HER2-HER3异构和脱乙FOXA1的协调活动避免了激素反应

Shixiong Wang1, Gemma Santacana-Font2, Darek Kedra2

  • 1Cell cycle regulation group, Institute of Biosciences (IBV), University of Oslo, Kristine Bonnevies hus, Blindernveien 31, 0371 Oslo, Norway.

Nucleic acids research
|November 12, 2025
PubMed
概括

通过改变FOXA1乙化,HER2信号影响乳腺癌,影响其DNA结合和对内分泌治疗的反应. 这突出了一个新的治疗点,涉及HER2/HER3-HDAC2-FOXA1通路.

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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
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