在小儿桃体切除术中Sugammadex和与出现相关的呼吸系统不良事件:一个随机对照试验
Sang-Hwan Ji1, Pyoyoon Kang2, Jung-Bin Park1
1Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Anesthesia and pain medicine
|November 12, 2025
概括
在小儿桃体切除术患者中,Sugammadex提供比neostigmine更快的神经肌肉阻塞逆转. 然而,它不会减少呼吸事件或输出管的时间,可能会增加出现 Delirium.
科学领域:
- 麻醉学 麻醉学
- 儿科手术 儿科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 苏加马德克斯对儿童出现相关呼吸系统事件的影响尚未得到充分证实.
- 这项研究调查了小儿桃体切除术患者的sugammadex与neostigmine的对比.
研究的目的:
- 为了比较sugammadex和neostigmine在小儿桃体切除术中逆转神经肌肉阻塞的疗效和安全性.
- 评估与出现相关的呼吸系统不良事件和的发生率.
主要方法:
- 一项随机试验,涉及172名儿童 (2-6岁) 接受桃体切除术.
- 患者接受了sugammadex或neostigmine用于神经肌肉阻塞逆转.
- 主要结局:呼吸系统不良事件;次要结局:排气时间,妄想,心肌梗塞,过敏反应.
主要成果:
- 苏加马德克斯显示显著更快的神经肌肉阻塞逆转 (1分钟与4分钟相比,P<0.001).
- 排卵的时间和整体呼吸系统不良事件发生率在各组之间相似 (分别P = 0.679和P = 0.858).
- 在苏加马德克斯组中出现妄的频率更高 (34.9%对20.9%,P = 0.044).
结论:
- 苏加马德克斯可以加速神经肌肉阻塞的逆转,但不能改善输出时间或减少小儿桃体切除术中的呼吸道并发症.
- 在这群人群中使用苏加马德克斯可能与出现狂妄症的发病率更高有关.
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