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Neslihan Sari¹, Hasan Basri Savaş¹, Seda Uğraş¹

¹From the Department of Otolaryngology (Sari, Durucu), from the Department of Biochemistry (Savaş), from the Department of Physiology (Uğraş), Mardin Artuklu University Medical Faculty, and from the Clinic of Otorhinolaryngology (Sari, Durucu), Mardin, Turkey.

Saudi medical journal

|November 12, 2025

概括

中性粒细胞与淋巴细胞比率 (NLR) 和全身免疫炎症指数 (SII) 的升高与通风管插入 (VTI) 后的髓硬化发展有关. 对于这种情况,NLR显示了适度的预测值.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
免疫学免疫学免疫学
儿科儿科儿科

背景情况:

髓硬化是通风管插入 (VTI) 的常见后果,涉及耳膜化.
系统性炎症标志物,如中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR) 和系统性免疫炎症指数 (SII),越来越多地被认为是它们在各种炎症状况中的作用.

研究的目的:

调查手术前的NLR,PLR和SII水平与VTI后儿童中神经硬化存在的关联.
评估这些炎症标志物对神经硬化症发展的预测潜力.

主要方法:

一项描述性病例对照研究包括75名儿童 (年龄在6-12岁) 具有VTI病史,分为髓硬化阳性 (n=43) 和髓硬化阴性 (n=32) 组.
进行了手术前血液样本分析,以计算NLR,PLR和SII. 使用统计方法评估人口统计因素,预后风险因素以及参数的辨别力.

主要成果:

患有神经样硬化症的儿童与没有神经样硬化症的儿童相比,在手术前的NLR,PLR和SII值显著更高 (p<0.05).
接收器操作特征 (ROC) 曲线分析表明,NLR在曲线下的面积最高 (0.76),这表明对神经样硬化有适度的预测能力.
较高的NLR被确定为神经硬化症的潜在预测因子,其灵敏度为0.63和特异性为0.78.

结论:

在VTI后的神经硬化症的背景下,NLR和SII作为全身炎症预后标志物.
升高的NLR是神经样硬化发展的适度预测因素,突出其潜在的临床相关性.
需要进一步的研究来确定有助于神经样硬化发展的额外参数.

关键词:

淋巴细胞淋巴细胞.神经硬化是一种神经硬化症 (myringosclerosis).作为一个中性恋者.血性中耳炎中耳炎

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