乳腺神经内分泌瘤:不断发展的概念和对分类的重新评估
1Pathology Department, Academic Unit for Translational Medical Sciences, School of Medicine, The University of Nottingham, Nottingham, UK; Pathology Department, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Surgical pathology clinics
|November 12, 2025
概括
乳腺癌中神经内分泌 (NE) 差异化存在诊断方面的挑战. 本文阐明了乳腺神经内分泌瘤 (NEN) 的病理评估,有助于分类和理解.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 内分泌学 在内分泌学.
背景情况:
- 乳腺癌表现出不同的分化模式,影响临床行为和治疗.
- 乳腺瘤中神经内分泌 (NE) 差异化会造成组织学异质性和诊断复杂性.
- 特定的实体,如固体乳头癌,粘膜癌和无特殊类型的侵入性癌症,可以显示NE特征.
研究的目的:
- 为了澄清乳腺神经内分泌瘤 (NENs) 的病理评估.
- 解决NE分化在乳腺瘤中所带来的诊断和分类挑战.
- 提供具有NE特征的已知瘤类型和罕见的原发性乳腺NENs的全面概述.
主要方法:
- 具有神经内分泌特征的乳腺瘤的组织病理学审查.
- 对分类乳腺神经内分泌瘤 (NENs) 的诊断标准的分析.
- 关于已知的瘤类型和乳腺罕见的初级NENs的文献综述.
主要成果:
- 具有NE分化的乳腺瘤在组织学上是多样化的.
- 诊断挑战来自乳腺癌中NE模式的频谱.
- 包括公认的实体和罕见的原发性神经内分泌瘤 (NEN).
结论:
- 准确的病理评估对于了解乳腺NENs至关重要.
- 澄清诊断标准有助于对这些异质瘤进行分类.
- 改进的理解支持与NE特征的乳腺癌的量身定制的临床管理.
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