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瘤透淋巴细胞在乳腺癌:为什么有用知道?

Sai K Maley¹, Reena Khiroya², Elena Provenzano³

¹NSABP Division of Pathology/ NRG Oncology Biospecimen Bank, 100 South Commons, Suite #120, Pittsburgh, PA 15212, USA.

Surgical pathology clinics

|November 12, 2025

概括

侧向瘤透淋巴细胞 (sTILs) 是乳腺癌中的一个有价值的生物标志物,可以预测结果和治疗反应. 较高的sTILs得分与更好的化学疗法和免疫疗法反应相关.

科学领域:

在瘤学瘤学.
病理学病理学病理学
免疫学免疫学免疫学

背景情况:

侧向瘤透性淋巴细胞 (sTILs) 是乳腺癌中容易评估的组织病理生物标志物.
sTILs在各种乳腺癌亚型中显示出预后和预测价值,包括三阴性 (TNBC),HER2阳性 (HER2+) 和高风险的光线乳腺癌.

研究的目的:

突出STILs在乳腺癌中的预后和预测意义.
强调STILs在预测对新辅助化疗和免疫疗法的反应中的作用.
探索STILs在指导乳腺癌治疗策略中的潜力.

主要方法:

使用标准光显微镜在用血素和素 (H&E) 染色的幻灯片上评估sTILs.
评估涉及量化瘤层内的淋巴细胞密度.
sTILs得分与临床结果和病理反应的相关性.

主要成果:

在基线活检上较高的sTILs得分与病理完整反应 (pCR) 的增加率有关.
升高的STIL预测患者在化学疗法和免疫疗法的反应中会有更好的结果.
sTILs作为一个强大的和可复制的生物标志物.

结论:

sTILs是乳腺癌中新辅助疗法反应的强有力的预测生物标志物.
sTILs可以为治疗降级或优化策略提供信息.
sTILs有助于选择可能受益于免疫治疗的患者.

关键词:

乳腺癌是什么? 乳腺癌是什么临床结果和免疫疗法 HER2阳性乳腺癌是什么激素受体阳性乳腺癌是什么流体瘤透到淋巴细胞中三重阴性乳腺癌是什么?

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