与非补偿性酒精相关肝硬化妇女死亡率相关的因素
J L Pérez-Hernández1, A D Santana-Vargas2, G Gutiérrez-Reyes3
1Servicio de Gastroenterología y Hepatología, Hospital General de México "Dr. Eduardo Liceaga", Mexico City, Mexico.
Revista de gastroenterologia de Mexico (English)
|November 12, 2025
概括
与酒精相关的肝硬化女性面临的死亡率高于男性,即使酒精消耗较低,饮酒时间较短. 这突显了女性与酒精相关的肝病结果的严重差异.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 与酒精有关的肝病 (ARLD) 是一个日益严重的全球健康问题.
- 增加女性的酒精消费增加了肝炎,肝硬化和肝癌的风险.
- 女性更容易受到酒精诱导的肝损伤的影响,导致死亡率和脱补偿风险更高.
研究的目的:
- 为了调查与酒精有关的肝硬化患者的女性患者的酒精消费模式.
- 评估和比较因酒精相关肝硬化住院的女性和男性之间的死亡率.
- 为了确定与这种患者群体的死亡率相关的因素.
主要方法:
- 在一个中心进行了一项回顾性队列研究,分析了2018-2021年192名患者记录 (50%为女性).
- 酒精消费模式被分为过度消费和暴饮暴饮.
- 使用卡普兰-梅尔曲线计算了生存率,而Cox比例危险模型确定了死亡率预测因素.
主要成果:
- 妇女在较晚的平均年龄开始慢性饮酒 (18岁对16.5岁),每次饮酒量较少 (140克对275克).
- 第一次住院期间的整体死亡率为32.8%,女性的死亡率明显高 (61.9%与38.9%).
- 与男性 (37.0年) 相比,女性的平均存活年龄 (33.8年) 较低,女性的性别是死亡率的重要预测因素 (OR=4.1).
结论:
- 与酒精有关的死亡率在女性中不成比例地高于男性.
- 导致女性死亡率较高的因素包括总体饮酒量较低,慢性饮酒持续时间较短,发病时年龄较大.
- 这些发现凸显了针对性干预和提高对女性酒精相关肝病风险的认识的需要.
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