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Updated: Jan 6, 2026

Author Spotlight: Universal Molecular Retention with 11-Fold Expansion Microscopy
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通过组织扩张实现微米分辨率的深层空间蛋白质组学

Fengxiang Wang1,2,3,4,5,6, Cuiji Sun2,3,4, Tianshu William Wu1,2,3,4,5,6

  • 1Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.

Nature
|November 12, 2025
PubMed
概括

我们通过扩展 (iPEX) 开发了现场成像蛋白质组学, iPEX以高分辨率绘制组织中的蛋白质,揭示早期阿尔茨海默病的变化和脂质代谢障碍.

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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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