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来自Pastinaca sativa的生物工程银纳米颗粒的抗菌特性,用于内治疗中的Enterococcus faecalis生物膜

Amir Ali Didar¹, Shaghyegh Ghadimi², Ailar Yousefbeigi³

¹Department of Endodontics, School of Dentistry, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.

Scientific reports

|November 12, 2025

概括

使用Pastinaca sativa根提取物 (Ag@PSR) 合成的银纳米颗粒显示出针对Enterococcus faecalis的显著抗菌和抗生物膜活性. 这些Ag@PSR纳米粒子有望提高内牙治疗成功率.

科学领域:

纳米技术纳米技术
生物材料科学生物材料科学
微生物学微生物学

背景情况:

内牙治疗的成功受到持续的Enterococcus faecalis感染的挑战.
新型抗菌和抗生物膜剂对于预防内牙治疗失败至关重要.
银纳米粒子 (AgNPs) 具有强大的抗菌特性.

研究的目的:

使用Pastinaca sativa根提取物 (Ag@PSR) 合成和表征银纳米颗粒.
评估Ag@PSR纳米颗粒的抗菌,抗生物膜和抗氧化特性.
探索Ag@PSR作为内牙治疗辅助的潜力.

主要方法:

使用Pastinaca sativa根提取物作为减少和稳定剂合成Ag@PSR纳米颗粒.
通过UV-Vis光谱学优化合成参数.
纳米粒子的表征涉及到XRD,FTIR,FESEM和TEM.
通过各种测试,评估了抗菌,抗生物膜和抗氧化活性.

主要成果:

优化合成产生了统一的,球形的Ag@PSR纳米粒子 (15-40nm).
Ag@PSR显示出对Enterococcus faecalis (MIC 500μg/mL) 的显著抗菌活性.
Ag@PSR减少了E. faecalis生物膜的形成86.7%,并表现出91%的DPPH激素清除活性.

结论:

Ag@PSR纳米颗粒具有有前途的抗菌,抗生物膜和抗氧化特性.
这些纳米颗粒可以成为治疗口腔感染的牙科材料的宝贵补充.
Ag@PSR显示了提高内牙治疗结果的巨大潜力.

关键词:

抗生物膜是一种抗生物膜.抗菌剂抗菌剂抗菌剂牙周内科医院牙周内科医院牙周内科医院绿色合成是一种绿色合成.帕斯蒂纳卡萨维亚 (Pastinaca sativa) 是一种植物.银纳米颗粒银纳米粒子

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