口腔免疫的创新生物标志物:进展和临床应用
Amin Gasmi1,2, Asma Gasmi Benahmed3, Amine Nehaoua4,5
1Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France.
Advances in experimental medicine and biology
|November 12, 2025
概括
口腔免疫的生物标志物,包括遗传,蛋白质组,代谢组和微生物组类型,为诊断和治疗口腔疾病提供了新的方法. 这些标志物对查,预后和针对性治疗诸如牙周炎和口腔癌等疾病有前途.
科学领域:
- 口腔免疫学和诊断的口腔免疫学和诊断.
- 生物标志物的发现和应用.
背景情况:
- 口腔免疫对健康至关重要,但其失调会导致难以管理的疾病.
- 生物标志物为免疫事件,疾病原因和口腔健康治疗有效性提供了洞察力.
研究的目的:
- 审查口腔免疫生物标志物的当前趋势.
- 涵盖口腔健康的遗传,蛋白质组,代谢组和微生物组生物标志物.
主要方法:
- 对口腔免疫生物标志物的现有文献的审查.
- 分析单核酸多态性 (SNP),副本数变化 (CNV),细胞因子,矩阵金属蛋白酶 (MMP),抗微生物 (AMP),代谢学和微生物组数据.
- 探索高通量查,多组学和计算生物学方面的进展.
主要成果:
- 遗传生物标志物 (SNP,CNV) 提高对口腔疾病风险和治疗的理解.
- 蛋白质生物标志物 (细胞因子,MMP,AMP) 改善疾病诊断,预后和治疗评估.
- 代谢和微生物组生物标志物提供了对生化途径和宿主微生物群相互作用的见解.
结论:
- 分子生物标志物具有查,预后和针对性治疗口腔疾病的潜力,如牙周炎,口腔癌和自身免疫性疾病.
- 在标准化生物标志物使用,监管批准和临床应用的经济可行性方面仍然存在挑战.
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