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Updated: Jan 11, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

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在T细胞中通过TRIM25剥离破坏VISTA,增强了癌症免疫治疗的潜力

Yishuang Sun1,2,3, Zijian Zhang4,5, Haiou Li6

  • 1Department of Hepatobiliary and Pancreatic Surgery, State Key Laboratory of Metabolism and Regulation in Complex Organisms, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China.

Cell research
|November 12, 2025
PubMed
概括

研究人员发现,TRIM25稳定了VISTA,这是癌症免疫治疗的关键目标. 破坏这种相互作用可以增强抗瘤免疫力,改善对PD-1/PD-L1阻塞和CAR T细胞治疗的反应.

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