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下一代3D打印多用途的阴道内环,用于持续配送抗逆转录病毒药物和避孕激素

Denali K Dahl¹, Rima Janusziewicz^1,2, Roopali Shrivastava¹

¹Lampe Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Pharmaceutical research

|November 12, 2025

概括

这项研究开发了一种3D打印的阴道内环 (IVR),用于输送预防艾滋病毒,HSV-2和怀孕的药物. 多用途预防技术 (MPT) IVR显示出有希望的药物释放和稳定性,为女性提供了更多的选择.

科学领域:

生物医学工程生物医学工程
生殖健康生殖健康
预防传染病预防传染病

背景情况:

妇女中艾滋病毒和HSV-2的高患病率需要综合预防策略.
阴道内环 (IVR) 是一种经过验证的药物输送平台,适合多用途预防技术 (MPT).

研究的目的:

开发和描述3D打印的IVR作为MPT提供抗HIV,抗HSV和避孕药物.
评估新型IVR的药物释放动力学,稳定性和生物相容性.

主要方法:

使用连续液体接口生产 (CLIPTM) 3D打印与尿树脂制造IVR.
使用溶剂膨胀将达皮维林 (DPV),普里特利维尔 (PTV) 和莱沃诺格斯特雷尔 (LNG) 装入IVR.
评估药物释放动力学,加速稳定性,以及体内/体外生物相容性.

主要成果:

3D打印的IVR显示了DPV,PTV和LNG的零顺序释放动力学,超过了DPV和LNG的治疗目标.
在加速储存6个月后,IVR保持了物理完整性;DPV是稳定的,而PTV和LNG显示退化.
安慰剂IVRs表现出100%的细胞活力,并且在体内耐受良好.

结论:

3D打印的MPT IVR是一种可行的一流技术,可同时预防艾滋病毒,HSV-2和怀孕.
这一创新有可能显著扩大全球年轻女性和女孩的预防选择.

关键词:

通过3D打印打印3D打印.避孕药是一种避孕药,用于避孕.有控制的药物输送.艾滋病病毒艾滋病病毒艾滋病病毒在HSV-2病毒中,阴道内环阴道内环

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