胆汁酸代谢在克罗恩氏病的系统综述:对病变发生和治疗干预的影响
Tareq M Abubasheer1, Khaled Saad2, Ahmed Altaweel3
1Faculty of Medicine, Al-Quds University, Gaza, Palestine.
Digestive diseases and sciences
|November 12, 2025
概括
克罗恩氏病与改变的胆酸 (BA) 代谢有关,显示二次BA减少和便分泌增加,特别是有胆汁问题. 这些变化可能会影响疾病的发展,并提供治疗点.
科学领域:
- 胃肠病学 胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
- 免疫学 免疫学 免疫学
背景情况:
- 克罗恩氏病 (CD) 是一种慢性炎症性肠道疾病,导致胃肠道炎症.
- 胆酸 (BA) 在消化和新陈代谢中起着至关重要的作用,它们的失调与各种疾病有关.
研究的目的:
- 系统地审查和分析克罗恩氏病和胆酸代谢之间的关系.
- 探索关于疾病活动,位置和CD患者手术史的BA组成的变化.
主要方法:
- 在主要数据库 (PubMed,Scopus,Embase,Cochrane,WOS) 进行了系统的文献搜索.
- 数据提取包括研究特征,患者人口统计和血清,肠道和便样本中的BA测量.
- 进行了包含的研究的质量评估.
主要成果:
- 分析了25项涉及656名CD患者和339名对照者的研究.
- 二次BAs (脱氧胆酸,石化胆酸) 在CD中减少,特别是在活跃的疾病或经过叶切除后.
- 在CD患者和对照人群中,总血清BA水平与CD患者和对照人群相似,但特定的合初级BA在食后下降.
结论:
- 克罗恩氏病表现出显著的胆酸代谢障碍,包括减少二次BA和增加便分泌.
- 皮质功能障碍,微生物失调和加速过渡是CD中这些BA变化的关键贡献者.
- 这些BA动态具有作为克罗恩病诊断生物标志物和治疗点的潜力.
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