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Updated: Jan 11, 2026

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组顺序设计和样本大小重新估计的好处随机对照试验评估的预防呼吸机相关的肺炎:一个模拟研究,由真实世界的数据提供信息

Holly Jackson1, Julien Sauser2,3, C H van Werkhoven4

  • 1Infection Control Program, Faculty of Medicine, Geneva University Hospitals, World Health Organization Collaborating Center, Geneva, Switzerland. holly.jackson@hug.ch.

BMC medical research methodology
|November 12, 2025
PubMed
概括

组序列设计 (GSD) 和样本大小重新估计 (SSR) 改善了随机对照试验 (RCT) 预防呼吸机相关肺炎 (VAP). 与固定RCT相比,这些自适应设计可以将预期的样本大小降低9-12%.

关键词:
适应性临床试验设计集团顺序设计 集团顺序设计随机的临床试验随机的临床试验对样本大小进行重新估计.与呼吸机相关的肺炎.

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