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肠道微生物群对牙周炎风险的因果关系:孟德尔随机化研究的元分析

Jianfeng Yu¹, Yuling Zuo¹, Lina Yang¹

¹Department of stomatology, Hospital of chengdu university of TCM, Chengdu, Sichuan, 610031, China.

BMC oral health

|November 12, 2025

概括

这项孟德尔随机化元分析揭示了肠道微生物群和牙周炎 (PD) 之间的因果关系. 特定的肠道细菌序列,属和物种被确定为增加或减少PD风险.

科学领域:

微生物组研究的研究.
牙周病学牙周病学
遗传流行病学遗传流行病学

背景情况:

牙周炎 (PD) 是一种常见的炎症性疾病,影响牙.
人们越来越认识到肠道微生物群在包括PD在内的全身性疾病中的作用.
特定的肠道细菌和PD之间的因果关系需要严格的调查.

研究的目的:

综合孟德尔随机化 (MR) 研究,以评估肠道微生物群和牙周炎 (PD) 之间的因果关系.
分析肠道细菌在各种分类层中的关联.

主要方法:

在五个数据库中系统搜索MR研究,将肠道微生物群 (序列/家族/属/物种) 与PD联系起来.
使用随机效应模型汇集研究水平的几率比率 (ORs).
使用Benjamini-Hochberg虚假发现率 (FDR) 控制多重性,并使用STROBE-MR和GRADE框架评估报告/确定性.

主要成果:

六项MR研究被纳入了分析.
肠杆菌和巴氏菌的订单与PD风险增加有显著的关联.
像Granulicatella和Prevotella唾液这样的特定属/物种增加了风险,而Butyricicoccus和Ruminiclostridium 6则显示出保护作用.

结论:

这一元分析提供了特定肠道细菌在牙周炎风险中的因果关系的证据.
识别了增加风险和改变风险的肠道种类,可以指导未来的预防和机制研究.

关键词:

因果关系是因果关系.我们的肠道微生物群.门德尔的随机化进行元分析分析.微生物标记物微生物标记物牙周病是指牙周病的发生.

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