COVID-19对垂体功能的影响:伊朗南部的一项横截面研究
Setare Sheikhi1, Farnaz Kamali Haghighi Shirazi2, Ali Zamani2
1School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC endocrine disorders
|November 12, 2025
概括
COVID-19 患者经常表现出荷尔蒙失衡,包括非甲状腺疾病综合征和阴性双胞胎症. 虽然这些异常与炎症相关,但它们不能预测疾病的严重程度,除了已故患者的较低T3外.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 内部医学 内部医学
背景情况:
- COVID-19与多器官功能障碍有关,影响内分泌系统.
- 严重的COVID-19病例经常伴有内分泌代谢并发症.
研究的目的:
- 为了调查伊朗住院COVID-19患者的荷尔蒙轴.
- 为了将荷尔蒙水平与疾病严重程度,结果和炎症生物标志物相关联.
主要方法:
- 在200名住院COVID-19患者的横截面研究.
- 评估了甲状腺,淋巴腺和上腺激素,以及益生菌.
- 使用COVID-19严重性指数评估疾病严重程度.
主要成果:
- 在183名患者中,26.8%患有非甲状腺疾病综合征 (NTIS),30.1%怀疑上腺功能不全.
- 95.5%的男性表现出阴性双胞胎缺陷症 (20.5%的初级,75%的二级).
- 激素水平与COVID-19的严重程度没有相关性;已故患者的T3较低,NTIS率较高. 在特定的荷尔蒙功能障碍中观察到高的C-反应蛋白和ESR.
结论:
- 住院COVID-19患者经常表现出荷尔蒙异常.
- 这些异常与炎症标志物相关,但与整体疾病严重程度无关.
- 较低的T3水平和较高的NTIS率与COVID-19患者的死亡率有关.
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