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血清补充C3作为代谢功能障碍的诊断生物标志物 - 中年和老年人中与脂肪性肝病相关的脂肪性肝病:一个横截面研究
Dan Ye1,2,3,4, Haifen Ma2,3,4, Jingjing Zhou2,3
1Department of Gastroenterology, Huadong Hospital Affiliated with Fudan University, Shanghai, China.
BMC gastroenterology
|November 12, 2025
概括
血清C3显示为老年人代谢功能障碍相关的脂肪性肝病 (MASLD) 的诊断生物标志物. 虽然C3水平与MASLD有关,但它们似乎与该人群中显著的肝纤维化无关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是导致慢性肝病的全球主要原因.
- 在MASLD中显著的肝纤维化 (SLF) 影响临床结果.
- 补充系统激活在MASLD中的作用及其在老年人群中的临床意义需要进一步研究.
研究的目的:
- 为了研究血清补充水平 (C1q,C3,C4,总活性) 和MASLD之间的关联.
- 为了评估血清补充水平和中年和老年人显著肝纤维化 (SLF) 之间的关系.
- 评估补充蛋白对MASLD的诊断性能.
主要方法:
- 对266名MASLD患者 (年龄≥45岁) 和150名年龄/性别匹配的对照进行了横截面研究.
- 多变量逻辑回归和受限立方线用于预测器识别和非线性关系评估.
- 斯皮尔曼的相关性,调解分析和ROC曲线分析用于临床关联和诊断性能评估.
主要成果:
- 与对照组相比,MASLD患者的血清C1q,C3,C4和总补充活性较高.
- 血清C3与MASLD独立相关 (OR=1.04每毫克/分升),非线性反转U形关系的峰值为143毫克/分升.
- C3显示MASLD的高诊断准确性 (AUC=0.80),与现有模型相比较;补充剂水平和SLF之间没有发现显著的关联.
结论:
- 血清C3是中年和老年人中MASLD的潜在诊断生物标志物,表现出明显的非线性关联和强烈的辨别能力.
- 在这个队列中,补充水平与肝纤维化没有独立相关.
- 需要进一步的纵向研究来确认C3在MASLD诊断中的临床实用性,并了解其潜在机制.
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