使用整合性转录学和基因组学解开肺癌和类风湿性关节炎之间的联系
Heng Li1,2, Liping Ding3, Nini Li4
1Department of Rheumatology and Immunology, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen, 510632, China. lconstant@foxmail.com.
BMC cancer
|November 12, 2025
概括
类风湿性关节炎 (RA) 患者患肺癌 (LC) 的风险较高,原因是他们有共同的分子通路. 这项研究发现了常见的免疫系统变化,包括病毒反应和T细胞信号变化,这可能解释了RA患者的LC风险增加.
科学领域:
- 基因组学和转录基因组学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 类风湿性关节炎 (RA) 患者的肺癌发病率增加了30-40%.
- 关联RA和LC的潜在分子机制和遗传因素在很大程度上是未知的.
- 这项研究调查了RA和LC之间共享的遗传和转录基因关联.
研究的目的:
- 确定共同的分子机制和遗传因素,有助于增加风湿性关节炎患者的肺癌风险.
- 通过整合性转录学和基因组学分析探索潜在的共享途径.
- 发现基于差异表达基因的肺部疾病的新生物标志物.
主要方法:
- 分析了来自肺癌 (LC),类风湿性关节炎 (RA) 和健康对照队伍的全基因表达数据.
- 下一代测序 (NGS) 确定了RA患者的基因组变异,包括患有并发性LC和间歇性肺病 (ILD) 的患者.
- 生物信息学工具被用来识别差异表达基因 (DEG) 和整合基因组数据用于途径分析.
主要成果:
- 1,051个差异表达的基因 (DEGs) 是常见的LC和RA,观察到不同的调节模式.
- 与免疫相关的共享途径改变包括上调的病毒反应和免疫信号,以及下调的T细胞受体 (TCR) 信号和T细胞激活.
- 在淋巴细胞/白细胞迁移和编程细胞死亡中发现了相反的调节模式,实验室测试证实了淋巴细胞的变化.
结论:
- 在LC和RA之间共享的病理机制可能涉及增强的病毒反应和减弱的T细胞信号和激活.
- 这些免疫失调可能导致RA患者肺癌风险升高.
- 具有相反调节模式的差异表达基因为肺部疾病提供了潜在的新生物标志物.
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