针对急性胰腺炎患者的腹内高血压的抗凝治疗
1Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
BMC gastroenterology
|November 12, 2025
概括
在急性胰腺炎 (AP) 患者中,抗凝固药物治疗可能会降低腹腔内高血压 (IAH). 这种治疗改善了炎症和疾病严重程度,但没有增加不良事件或死亡率.
科学领域:
- 胃肠病学 胃肠病学
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 腹腔内高血压 (IAH) 是急性胰腺炎 (AP) 的常见并发症,可能导致多器官衰竭.
- 抗凝固药治疗在AP患者的IAH管理中的治疗作用仍然不确定.
研究的目的:
- 研究抗凝固药疗法在被诊断为急性胰腺炎 (AP) 的患者中减轻腹内高血压 (IAH) 的疗效.
主要方法:
- 对49名IAH的AP患者进行了回顾性分析,比较了34名接受抗凝剂治疗的患者和15名没有接受抗凝剂治疗的患者.
- 评估的关键结果包括腹内压力,炎症标志物,疾病严重程度 (修改的马歇尔得分) 和成像发现.
主要成果:
- 接受抗凝剂治疗的患者在60小时后表现出明显降低的腹内压力.
- 在7天后,在抗凝剂组中观察到炎症标志物和修改的马歇尔评分的改善.
- 两组之间在成像指数,住院,死亡率,静脉血栓症或门脉高血压方面没有发现显著差异.
结论:
- 抗凝固药疗法在急性胰腺炎患者的腹内高血压中呈现出一种潜在的治疗策略.
- 治疗证明安全,没有报告出血或过敏反应的不良反应.
- 需要进一步的研究,以充分阐明抗凝药在这种患者群体中的长期益处和最佳使用.
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