在活病毒暴露后,根据TOSc样本对母猪的PRRSVRNA阳性随时间推移的特征动态和相关风险因素
Peng Li1, Paul Yeske2, Swami Jayaraman1
1Veterinary Diagnostic and Production Animal Medicine, Iowa State University College of Veterinary Medicine, Ames, IA, USA.
BMC veterinary research
|November 12, 2025
概括
随着时间的推移,猪生殖和呼吸系统综合征病毒 (PRRSV) 的RNA阳性性在母猪中下降,在活病毒接种后16周内达到低患病率. 较高的平价与PRRSVRNA阳性降低有关,而生育母猪在低患病率期间呈现出较高的阳性.
科学领域:
- 兽医病毒学 兽医病毒学
- 猪健康管理 猪健康管理
- 疾病控制和消灭
背景情况:
- 在母猪中未检测到的猪生殖和呼吸系统综合征病毒 (PRRSV) 是控制小猪的PRRSV的主要障碍.
- 缺乏实用的个体母猪采样工具,阻碍了对PRRSV持久性动态的理解.
- 这项研究解决了使用新型采样方法在母猪中描述PRRSVRNA阳性动态的需要.
研究的目的:
- 描述PRRSVRNA阳性在母猪在一个完整的繁殖周期的动态.
- 用实用的桃体-口腔-洗 (TOSc) 采集方法识别与PRRSVRNA阳性相关的风险因素.
- 评估在商业群体中活病毒接种 (LVI) 后的PRRSV持久性.
主要方法:
- 在一家商业繁殖至断奶农场进行了实地研究,该农场实施了群体关闭和LVI疫情后的实施.
- 在LVI前和后的四周间隔,使用TOSc方法采样了275头母猪,最多为24周.
- 母猪按平价 (P0,P1-2,P3+) 和生产阶段 (剥离品种,孕期,繁殖) 分类.
主要成果:
- 随着时间的推移,PRRSV RNA阳性度下降,在LVI后16周达到4.43%,表明患病率低的情况.
- 在LVI.后24周观察到阳性反弹到8.00%.
- 较高的平价显著降低了PRRSVRNA阳性,而生育阶段的母猪在低流行时期呈现出较高的阳性.
结论:
- 通过TOSc样本评估的母猪的PRRSVRNA阳性随着时间的推移而下降,并在LVI后16周实现了低流行率.
- 增加的母猪平价显著与降低的PRRSVRNA阳性相关.
- 生产阶段对PRRSVRNA阳性的影响在低患病率情景中更为明显.
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