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在患心力衰竭风险人口中,蛋白质器官衰老和心脏代谢风险
Kaiyong Qu1, Elisa Dal Canto2,3, Anne-Mar L N van Ommen2
1Laboratory of Experimental Cardiology, University Medical Center Utrecht, Room Number G02-404, Utrecht University, Utrecht, The Netherlands. qukaiyong821@163.com.
Cardiovascular diabetology
|November 12, 2025
概括
器官衰老加速 (OAA) 与心力衰竭 (HF) 严重程度有关,观察到性别特定的模式. 糖尿病和代谢因素,如甘油三-葡萄糖体重指数 (TyG-BMI),有助于加速器官衰老.
科学领域:
- 生物医学科学 生物医学科学
- 老年学是一门学科.
- 心脏病学 心脏病学
背景情况:
- 生物衰老在个体和组织之间有所不同,影响诸如心力衰竭 (HF) 等慢性疾病.
- 器官特异性衰老加速 (OAA) 可以使用蛋白质组技术量化.
- OAA,HF严重程度和性别差异之间的关系尚未得到充分理解.
研究的目的:
- 评估心脏,动脉和脏中的OAA与HF严重程度之间的与性别相关的关联.
- 调查与加速器官衰老相关的心脏代谢风险因素.
主要方法:
- 利用血蛋白学来估计556名参与者的心脏,动脉和脏的生物年龄.
- 计算的OAA是从时间学年龄的偏差.
- 采用回归模型来评估OAA,HF阶段,心声学参数和心脏代谢风险因素之间的关联,包括TyG-BMI等复合指数.
主要成果:
- 两性中心脏OAA与晚期HF (C/D阶段) 相相关;动脉OAA仅在女性中与HF有关.
- 多器官衰老 (≥2个具有OAA的器官) 将高级HF的几率增加了三倍以上.
- 糖尿病是动脉和脏OAA的关键因素,而较高的TyG-BMI与女性的晚期脏OAA有关.
结论:
- 蛋白质组衍生的OAA与HF严重程度有关,表现出潜在的性别特异性模式.
- 糖尿病和提升的TyG-BMI与加速器官衰老有关,这表明与代谢功能障碍共同的衰老机制.
- 这些发现突显了代谢健康,器官衰老和心力衰竭进展之间的相互作用.
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