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青少年纤维肌痛心率变化 (HRV):一项初步研究

Federico Diomeda¹, Brigitte Dell'Anna², Rossella Greco²

¹Pediatric Rheumatology and Immunology Unit, 'Vito Fazzi' Hospital, Piazza Muratore 1, 73100, Lecce, Italy. Federicodiomeda91@gmail.com.

Pediatric rheumatology online journal

|November 12, 2025

概括

患有青少年纤维肌痛 (JFM) 的儿童心率变化 (HRV) 连贯性较低,表明自主调节失调. 这种生理差异与JFM患者的疼痛和焦虑增加有关.

科学领域:

儿科风湿病学儿科风湿病学
自主神经系统研究自主神经系统研究
疼痛管理疼痛管理

背景情况:

青少年纤维肌痛 (JFM) 是儿童和青少年的一种慢性疼痛疾病.
自主调节失调,以减少心率变化 (HRV) 表示,与JFM症状严重程度有关.
情绪上的痛苦经常与JFM同时发生.

研究的目的:

调查JFM和没有JFM的儿童之间的临床,情绪和生理差异.
探索自主功能,特别是HRV在儿科纤维肌痛中的作用.
为了确定JFM的潜在生物标志物.

主要方法:

在JFM和对照组中对30名参与者 (8-17岁) 进行了观察性,横截面研究.
临床评估包括普遍疼痛指数 (WPI),症状严重程度量表 (SSS),数值评分量表 (NRS) 和儿童多维焦虑量表 (MASC-2).
使用emWave Pro测量心率变化 (HRV) 的连贯性;统计分析包括威尔科克森测试,斯皮尔曼相关性和后勤回归.

主要成果:

患有JFM的儿童表现出明显更高的疼痛和焦虑水平 (p < 0.001).
在JFM组中观察到显著较低的HRV连贯性 (平均值0.91对1.27;p <0.01).
在HRV和症状严重程度 (WPI,SSS) 和焦虑水平之间发现了反向相关性.

结论:

减少HRV连贯性与儿科纤维肌痛症状负担增加和心理痛苦有关.
HRV可以作为JFM的潜在生物标志物.
HRV生物反为管理青少年自主调节和慢性疼痛提供了一个有希望的非药物治疗策略.

关键词:

焦虑焦虑是一种焦虑.自主性的功能障碍.生物反的回报慢性疼痛是一种慢性疼痛.人权和人权愿景的一致性心率变化心率的变化.青春期纤维肌痛是一种青少年纤维肌痛.非药物治疗的非药物治疗.儿科风湿病学儿科风湿病学症状严重程度症状严重程度

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