药剂师在癌症患者中基于协议的药理疗管理的有用性:一项追溯观察性研究
Satomi Sumikawa1, Noriaki Hidaka2, Yuya Sakamoto1
1Division of Pharmacy, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Journal of pharmaceutical health care and sciences
|November 13, 2025
概括
基于协议的药疗管理 (PBPM) 在接受化疗的癌症患者中改善了实验室测试的遵守性. 这种增强的坚持确保了更安全的治疗和更好的患者结果.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 基于团队的护理对于高质量的癌症治疗至关重要.
- 埃希梅大学医院实施了三种基于协议的药理疗管理 (PBPM) 策略,以优化化疗护理并减少医生的工作负担.
- 这些策略涉及乙型肝炎病毒 (HBV) 再激活,尿蛋白/肌素比率 (UPC) 监测和血清水平.
研究的目的:
- 评估三种PBPM策略在门诊化疗环境中的有效性.
- 评估PBPM对实验室测试符合性对特定患者监测的影响.
- 确定PBPM是否提高了癌症治疗的安全性和效率.
主要方法:
- 使用了比较性研究设计,分析了从2021年7月到2023年2月的患者数据.
- 在PBPM实施前和之后的六个月内,测量了对实验室测试的遵守率.
- 该研究的重点是HBV-DNA量化,UPC测量和血清的监测.
主要成果:
- 符合HBV-DNA量化水平显著增加,从PBPM后的66.3%增加到86.7% (p=0.002).
- 在PBPM实施后,HBV-DNA测试不合格的中位数持续时间显著减少 (p=0.021).
- 虽然对UPC和血清的遵守率仍然很高,并且显示出轻微的改善,但这些变化在统计学上并不显著.
结论:
- 基于协议的药理疗管理 (PBPM) 有效地提高了在化疗期间癌症患者遵守必要的实验室测试.
- 通过确保及时和适当的监测,PBPM的实施有助于更安全的癌症治疗.
- 这些发现支持将PBPM策略纳入临床实践,以改善患者护理和安全.
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