药品同情使用趋势:以色列 2020-2024年
Eyal Schwartzberg1,2,3, Eli Marom4, Victoria Finkel-Pekarsky5
1Clinical Pharmacy and Regulatory Management MSc. Program, School of Pharmacy, Health Sciences Faculty, Ben Gurion University, Beer Sheva, Israel. eyalsh@bgu.ac.il.
Israel journal of health policy research
|November 13, 2025
概括
以色列的同情使用计划加速了对严重疾病的新疗法的获取. 然而,利用率的下降趋势和潜在的访问差异需要进一步调查.
科学领域:
- 医学研究 医学研究
- 卫生政策 卫生政策
- 药物开发 药物开发
背景情况:
- 富有同情心的使用计划为患有严重或危及生命的疾病的患者提供试验性疗法,当标准治疗方法不足时.
- 这些计划在弥合药物开发和广泛临床可用性之间的差距方面发挥着至关重要的作用.
研究的目的:
- 分析以色列同情使用计划中的药品利用趋势,结果和模式.
- 评估影响这些疗法的普及和可访问性的因素.
主要方法:
- 分析了以色列卫生部同情使用数据库 (2020-2024) 的匿名数据.
- 使用统计方法,包括学生的t测试和千二测试,以确定显著的亚组差异 (p < 0.05).
- 通常使用的产品与卫生部数据库进行了交叉引用,以获得注册和退款状态.
主要成果:
- 超过3,284次治疗涉及596种不同的产品,用于1,361种疾病.
- 2020年治疗的峰值发生,随后下降;65-80岁患者的利用率最高.
- 最常用的产品是Belantamab mafodotin和Trametinib;60%的常见疗法后来被纳入国家健康篮子.
结论:
- 以色列的同情使用计划有助于早期获得新型疗法,并有助于将其整合到国家卫生篮子中.
- 发现了利用率的令人担忧的下降趋势和潜在的访问差异.
- 需要进行进一步的有针对性的调查,以解决利用趋势,并确保公平地获得研究治疗.
相关概念视频
01:29Issues And Trends In Healthcare Delivery System
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
01:02Prescription, Nonprescription and Orphan Drugs
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
01:26Drug Administration and Therapy Phases: Overview
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
01:28Drug Products: Biologics, Biosimilars and Interchangeables
Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
01:26FDA Approved Drugs: Changes to Approved Drugs
Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
01:29Therapeutic Drug Monitoring: Affecting Factors
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.