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日本的类固醇依赖性性结肠炎患者的治疗模式和结果:一项索赔数据库研究
Masayuki Saruta1, Takumi Sugiyama2, Takumi Tajima2
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
在日本,超过一半的类固醇依赖性性结肠炎 (UC) 患者继续单独使用类固醇,在3个月内停止治疗的比例很低. 需要优化治疗,以便在UC管理中更好地遵守指南.
科学领域:
- 胃肠病学 胃肠病学
- 临床药房 临床药房
- 医疗保健服务研究 医疗服务研究
背景情况:
- 目前的指导方针建议在3个月内逐渐减少或停止治疗性结肠炎 (UC) 的类固醇治疗.
- 对于类固醇依赖的UC,建议开始提奥普林治疗或高级治疗.
- 日本对类固醇依赖性UC的现实世界治疗模式需要澄清.
研究的目的:
- 分析日本类固醇依赖性UC患者的现实治疗模式和结果.
- 评估对类固醇依赖性UC的治疗指南的遵守情况.
主要方法:
- 日本医学数据中心 (JMDC) 索赔数据的回顾性分析.
- 在2010年6月至2019年9月期间,确定了新UC诊断的患者.
- 确定关键日期:UC治疗开始,类固醇依赖的确认和治疗加剧.
主要成果:
- 在开始服用类固醇的986名患者中,429名 (43.5%) 是类固醇依赖者.
- 只有29.8%的人开始服用西奥普林,17.5%的人开始接受高级治疗,52.7%的人仅继续服用类固醇.
- 在所有组中,在3个月内停止使用类固醇的比例很低 (3-6%).
结论:
- 在日本,超过一半的依赖类固醇的UC患者继续接受类固醇单疗法.
- 观察到较低的早期类固醇断药率,无论随后是否开始先进治疗.
- 目前在日本的类固醇依赖性UC的管理需要改进治疗优化,以符合既定指南.
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