在台湾一般人口中,缺血性中风,出血性中风,痴呆和rs201118034之间的关联
Yi-Chia Liaw1,2, Che-Hong Chen3, Shu-Yi Hsu3
1Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|November 13, 2025
概括
NOTCH3 rs201118034变种在台湾成年人中显著增加了缺血性和出血性中风的风险. 然而,这种遗传因素似乎没有影响痴呆风险,这表明疾病的途径是不同的.
科学领域:
- 遗传学 遗传学 是一个
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 脑血管疾病,包括中风和痴呆症,对公共卫生构成重大挑战.
- 遗传因素,如单核酸多态 (SNP),越来越多地被认为是它们在疾病易感性中的作用.
研究的目的:
- 调查NOTCH3 rs201118034变种与缺血性中风,出血性中风和痴呆症风险之间的关联.
- 评估基于SNP的脑血管疾病风险分层的潜力.
主要方法:
- 分析了台湾生物库中的114,233名个体的数据,整合了临床诊断和遗传信息.
- 使用国际疾病分类 (ICD-9/ICD-10) 代码进行诊断分类.
- 包括30至70岁的参与者,没有癌症史.
主要成果:
- rs201118034 AG+AA基因型与缺血性中风 (OR:1.50,p < 0.001) 和出血性中风 (OR:2.21,p < 0.001) 的风险增加显著相关.
- 在rs201118034变体和痴呆风险之间没有发现显著的关联 (p = 0.326).
结论:
- NOTCH3 rs201118034变种在增加中风风险方面发挥作用,但对痴呆症的影响微不足道.
- 在脑血管疾病中,遗传和心血管因素至关重要.
- 基于SNP的风险分层可以帮助为具有特定基因型的个体制定有针对性的预防策略.
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