高血压和糖尿病作为永久性心房的患者报告生活质量的决定因素
Paul Gabriel Ciubotaru1, Nilima Rajpal Kundnani2,3, Abhinav Sharma2
1Department V, Internal Medicine I-Discipline of Medical Semiology I, Center of Advanced Research in Cardiology and Hemostasology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Diagnostics (Basel, Switzerland)
|November 13, 2025
概括
糖尿病显著降低了心房的高血压患者的生活质量,主要是由于功能障碍和炎症. 解决这些因素可能会改善患者的健康和结果.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 高血压和糖尿病常见于永久性心房动,恶化心血管结果.
- 与健康相关的生活质量 (HRQoL) 是疾病负担的关键指标.
- 堪萨斯城心肌病问卷 (KCCQ) 评估HRQoL,但其在高血压糖尿病患者和心房的使用是不充分探索的.
研究的目的:
- 评估糖尿病对高血压患者永久性心房的HRQoL的影响.
- 在这个人群中确定与HRQoL受损相关的临床因素.
主要方法:
- 对198名患有永久性心房的高血压患者进行了回顾性研究.
- 患者被分为仅有高血压 (仅有HTN) 和具有2型糖尿病 (HTN + DM) 的高血压.
- 分析了KCCQ得分,以及人口统计,实验室和心声学数据;多变量回归确定了HRQoL的预测因素.
主要成果:
- 平均KCCQ得分在HTN+DM组 (50.9±11.3) 与仅HTN组 (54.9±14.4,p=0.034) 相比较较低.
- 糖尿病患者表现出较差的功能,尿酸升高和炎症增加.
- 降低估计的膜过率 (eGFR),较高的中性粒细胞计数,较大的左心房体积和心力衰竭与减少的喷射率 (HFrEF) 是较低的KCCQ分数的独立决定因素.
结论:
- 糖尿病会对高血压患者的HRQoL产生负面影响,这些患者患有永久性心房动,由功能障碍,炎症和心脏重塑介导.
- 这些发现表明,向功能和炎症等途径可以提高患者感知到的健康和临床结果.
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