相关实验视频
Updated: Jan 11, 2026
06:09
Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
7.3K
综合呼出VOC和临床生物标志物分析,用于预测喘和COPD患者的支气管扩展剂反应
Malika Mustafina1,2,3, Artemiy Silantyev4, Aleksander Suvorov4
1Department of Cardiology, Functional and Ultrasound Diagnostics, I.M. Sechenov First Moscow State Medical University (Sechenovskiy University), 119991 Moscow, Russia.
Diagnostics (Basel, Switzerland)
|November 13, 2025
概括
呼出的挥发性有机化合物 (VOC) 可以将喘和COPD与健康个体区分开来. 将VOC与临床标记物相结合,可以准确预测阻塞性肺部疾病中支气管扩展剂反应率 (BDR).
科学领域:
- 肺部医学 肺部医学
- 分析化学 分析化学
- 生物标志物发现发现
背景情况:
- 喘 (BA) 和慢性阻塞性肺病 (COPD) 是常见的阻塞性肺病,具有共同的症状但不同的炎症.
- 支气管扩展剂反应 (BDR) 对于诊断至关重要,但其代谢基础仍然不清楚.
- 了解代谢差异可以帮助区分这些疾病并预测治疗反应.
研究的目的:
- 为了确定是否呼出的挥发性有机化合物 (VOC) 和临床生物标志物可以区分喘,COPD和健康状态.
- 研究这些生物标志物对支气管扩展剂反应 (BDR) 的预测能力.
- 探索呼吸分析和临床免疫学之间的协同作用,以实现个性化阻塞性肺病管理.
主要方法:
- 一项涉及160名喘患者,128名慢性肺炎患者和254名健康对照者的横截面研究.
- 使用质子转移反应飞行时间质谱法 (PTR-TOF-MS) 来实时分析呼出的呼吸.
- 临床评估包括螺旋测量,FeNO,血液中乙氨基和IgE,并使用机器学习 (XGBoost) 进行分析.
主要成果:
- 独特的VOC档案将疾病组与对照组以及彼此区分开来,准确度很高 (AUC从0.710到0.856不等).
- 挥发性有机物和临床生物标志物 (FeNO,乙素,IgE) 的组合模型在预测BDR方面取得了高准确性 (潮呼吸的AUC = 1.000,强迫呼吸的0.970).
- 特定的VOCs (m/z 79,m/z 101) 与积极的BDR.有很强的联系.
结论:
- 确定了特定疾病的VOC标志,突出了喘,COPD和健康对照之间的差异.
- 呼气代谢学和临床免疫学之间存在强大的协同作用,用于预测治疗反应.
- 实时呼吸分析为阻塞性肺部疾病的个性化管理策略提供了希望.
相关概念视频
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
01:26COPD: Management Using Bronchodilators and Corticosteroids
709
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
709
01:30Asthma-IV: Diagnostic and Management
3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
01:26Asthma-II: Pathophysiology and Classification
4.0K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.0K
01:20COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
01:25Pulmonary Function Tests
723
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
723