使用基于炎症的评分系统预测囊性纤维化肺部恶化
Raphael S Reitmeier1, Melanie Götschke1, Julia Walter1,2
1Department of Medicine V, LMU University Hospital, LMU Munich, 81377 Munich, Germany.
Diagnostics (Basel, Switzerland)
|November 13, 2025
概括
CRP/白蛋白比率有效预测肺部恶化 (PEx) 在患有囊性纤维化 (pwCF) 的人. 这种简单的标志物可以识别高风险的个体,帮助临床实践和PEx预防策略.
科学领域:
- 肺部病理学 肺部病理学
- 临床医学 临床医学
- 生物标志物 生物标志物
背景情况:
- 肺部恶化 (PEx) 对患有囊性纤维化 (pwCF) 患者的结果有显著影响.
- 预测PEx对于有效的管理和预防策略至关重要.
- 目前对PEx的定义缺乏普遍共识,使风险评估复杂化.
研究的目的:
- 为了识别患有囊性纤维化 (pwCF) 的个人,他们面临未来肺部恶化 (PEx) 的风险.
- 评估慢性炎症的既定和新型标志物,以预测PEx.
- 为了比较各种炎症标志物和评分系统在预测PEx的有效性.
主要方法:
- 在3年的时间内对131名患有囊性纤维化 (CF) 的成年人进行了回顾性分析.
- PEx定义为需要静脉注射抗生素治疗的需要.
- 炎症标志物的比较,包括CRP/白蛋白比率,中性粒细胞与淋巴细胞比率 (NLR) 和淋巴细胞与单细胞比率 (LMR),以及格拉斯哥预后得分 (GPS).
主要成果:
- 57.3%的pwCF在随访期间经历了PEx.
- 多变量分析确定CRP ((log),CRP/白蛋白比,降低LMR,增加NLR和GPS作为PEx的显著预测因素.
- 在pwCF中,CRP/白蛋白比率显示了PEx的最高预测性表现.
结论:
- 基于炎症的评分系统可以预测pwCF中的PEx.
- 易于计算的CRP/白蛋白比率可靠地识别了PwCF的PEx风险增加.
- CRP/白蛋白比率是管理PEx风险的临床应用的一个有希望的工具.
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