以色列的间歇性肺部疾病:在近距离的地理位置下存在很大的变化
Tzlil Hershko1,2, Ophir Freund1,2, Sonia Schneer3
1Institute of Pulmonary Medicine, Tel Aviv Sourasky Medical Center, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6423906, Israel.
Diagnostics (Basel, Switzerland)
|November 13, 2025
概括
间歇性肺病 (ILD) 在以色列显示区域差异. 边缘地区患有更多的异形性肺纤维化 (IPF),而中心地区患有更多与暴露相关的和自身免疫性ILD.
科学领域:
- 肺部病理学 肺部病理学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在以色列人口中没有关于间歇性肺部疾病 (ILD) 的先前综合报告.
- 以色列可能存在独特的流行病学特征,需要进行调查.
- 专注于以色列国内的区域差异,以了解ILD的流行率和特征.
研究的目的:
- 为了探索以色列ILD的流行病学.
- 识别和分析ILD诊断和患者人口统计的区域差异.
- 调查地理居住和ILD亚型之间的关联.
主要方法:
- 来自以色列四个高等医疗中心的连续ILD患者的回顾性分析.
- 多学科的ILD的诊断.
- 多变量回归模型用于评估居住 (边缘与中心) 对ILD亚型的影响.
主要成果:
- 包括927名ILD患者 (平均年龄67岁,女性40%).
- 尽管中心相邻,但在人口统计学,暴露和诊断方面观察到显著差异.
- 异形性肺纤维化 (IPF) 在外围地区更常见 (53%对24%),而与暴露相关的和自身免疫性ILD在中心地区更常见 (分别为16%对5%和25%对16%).
- 边缘居住独立预测IPF (AOR 2.95);中央居住预测与暴露相关的ILD (AOR 0.46).
结论:
- 在以色列境内,ILD特征存在显著的区域差异.
- 边缘居住是IPF的预测因素,而中心居住与暴露相关的ILD有关.
- 个性化ILD评估至关重要,考虑到当地的频率和环境暴露.
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