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在小儿肝母细胞瘤中微血管密度的非侵入性预测,使用对比增强超声波定量参数

Yazi You¹, Lirong Zhu¹, Hongli Zhai¹

¹Department of Ultrasound, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Key Laboratory of Children's Vital Organ Development and Diseases of Chongqing Health Commission, Chongqing 400014, China.

Diagnostics (Basel, Switzerland)

|November 13, 2025

概括

与对比度增强的超声波 (CEUS) 可以非侵入性地评估肝细胞母细胞瘤 (HB) 中的微血管密度 (MVD). CEUS参数,特别是相对冲洗率 (rWoR),与MVD相关,可以预测瘤血管性.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
医疗成像医学成像

背景情况:

肝母细胞瘤 (HB) 是一种儿科肝癌.
评估瘤血管性对于预测HB进展至关重要.
微血管密度 (MVD) 是瘤血管生成的一个关键指标.

研究的目的:

为了研究对比增强超声波 (CEUS) 参数和肝细胞母细胞瘤 (HB) 中的微血管密度 (MVD) 之间的关系.
评估CEUS作为预测HB进展和瘤血管性的非侵入性方法.

主要方法:

对34例儿科HB病例的回顾性分析.
用时间强度曲线 (TIC) 分析评估灰度超声波和CEUS.
通过CD34免疫组织化学作为参考标准来量化MVD.

主要成果:

高MVD病变显示出透血管的增加和阿德勒级血流.
在高和低MVD组之间,在TIC衍生和相对定量CEUS参数中观察到显著的差异.
相对冲洗率 (rWoR) 预测低MVD,灵敏度为76.9%,特异性为81.0% (AUC = 0.802).

结论:

CEUS参数与肝细胞瘤中MVD相关.
CEUS显示出作为一种非侵入性工具的潜力,用于表征HB的瘤血管性.
通过评估瘤血管生成,CEUS可能有助于预测HB进展.

关键词:

孩子们的孩子们的孩子们的孩子们.肝炎母细胞瘤是什么微型血管密度密度时间强度曲线.超声波学超声波学超声波学

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