脂肪组织功能障碍和代谢疾病:维生素D/维生素D受体轴的作用
Flavia Agata Cimini1, Federica Sentinelli2, Alessandro Oldani1
1Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy.
International journal of molecular sciences
|November 13, 2025
概括
维生素D及其受体 (VD/VDR) 调节脂肪组织功能,影响代谢健康. 维持足够的维生素D对于预防与肥胖相关的问题和代谢障碍至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 肥胖驱动的脂肪组织功能障碍是代谢障碍的核心,如2型糖尿病和心血管疾病.
- 维生素D/维生素D受体 (VD/VDR) 轴因其在调节脂肪组织恒温中的作用而越来越被认可.
- 维生素D的功能超越矿物代谢,影响脂肪生成,炎症和胰岛素敏感性.
研究的目的:
- 审查目前对脂肪组织中VD/VDR轴的理解.
- 探索分子途径和临床证据,将维生素D状态与与肥胖有关的并发症联系起来.
- 讨论遗传变异性和组织特异性VDR信号对代谢结果的影响.
主要方法:
- 关于脂肪组织中的分子通路的文献综述.
- 对维生素D和肥胖的实验和临床研究的分析.
- 讨论影响VDR信号的遗传和组织特异性因素.
主要成果:
- VD/VDR轴在调节脂肪循环和脂肪组织内的免疫反应方面发挥着重要作用.
- 维生素D状态与各种与肥胖相关的代谢并发症有关.
- 遗传变异和组织特定的VDR信号调节代谢健康结果.
结论:
- 适当的维生素D水平对于预防脂肪组织功能障碍和相关心脏代谢后果很重要.
- 虽然补充剂试验结果各不相同,但VDD/VDR轴对肥胖和代谢疾病具有治疗潜力.
- 需要进一步的研究来优化针对VD/VDR轴的策略,以治疗代谢性疾病.
关键词:
亚迪波基因 (Adipokine) 是一种可靠的药物.脂肪组织功能障碍这是一种炎症炎症炎症炎症.胰岛素耐药性是一种胰岛素耐药性.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖维生素D (VD) 是一种维生素.维生素D受体 (VDR) 是一种维生素D受体.更多相关视频
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