探索MASLD和IBD的重叠:从单个中心体验的见解
Ana Stemate1, Delia-Ionela Negru-Vodă2,1, Ana Maria Patricia Mazurencu-Pele2
1Department of Gastroenterology 1, Emergency University Hospital, Splaiul Independenței Street, No. 169, Sector 6, 050098 Bucharest, Romania.
International journal of molecular sciences
|November 13, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在炎症性肠病 (IBD) 中很常见. 尿酸/高密度脂蛋白胆固醇比率 (UHRatio) 显示,作为一种非侵入性工具,可用于在IBD患者中早期检测MASLD.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- MASLD是炎症性肠病 (IBD) 最常见的肠外并发症,包括克罗恩病 (CD) 和性结肠炎 (UC).
- 最近批准第一种MASLD治疗方法强调了需要改进诊断和查策略的必要性.
研究的目的:
- 调查IBD患者 (CD和UC) 中的MASLD患病率.
- 为了确定与IBD中MASLD相关的风险因素.
- 评估尿酸/高密度脂蛋白胆固醇比率 (UHRatio) 作为MASLD的非侵入性标记,并评估非侵入性纤维化得分 (FIB-4,APRI) 与组织纤维化.
主要方法:
- 一项前性研究,涉及58名被诊断患有IBD的患者.
- 评估MASLD的流行率和纤维化.
- 评估UHRatio,FIB-4和APRI用于预测肥胖症和纤维化严重程度.
主要成果:
- IBD类型与肝硬化或纤维化没有独立的相关性.
- 疾病活动与CD中的肝硬化和UC中的肝纤维化有显著的联系.
- UHRatio有效地表明了肥胖症的患病率,而FIB-4和APRI与纤维化严重程度没有相关性.
结论:
- 在IBD患者中,UHRatio显示出作为早期MASLD预测的非侵入性生物标志物的潜力.
- 这项研究是第一个探索UHRatio在IBD人口中MASLD查中的实用性.
- 在IBD患者中,UHRatio可以作为一种有价值的MASLD查工具.
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