自然杀手细胞活动和对乳腺癌患者新辅助治疗的反应
Sofie Høier Gamborg-Kvist1,2, Else Maae1, Signe Timm1,2
1Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.
International journal of molecular sciences
|November 13, 2025
概括
自然杀手细胞活性 (NKA) 显示了乳腺癌患者的预后潜力. 低NKA与较差的无侵袭性疾病生存率有关,并且发现普雷尼索隆会损害NKA测量.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
背景情况:
- 缺乏用于监测新辅助乳腺癌治疗反应的有效生物标志物.
- 自然杀手细胞活性 (NKA) 在各种癌症中表现出预后价值.
研究的目的:
- 研究接受新辅助治疗的乳腺癌患者的NKA和治疗反应之间的关联.
- 评估NKA作为乳腺癌结果的潜在预后生物标志物.
主要方法:
- 血干扰素-玛 (IFNγ) 水平被测量为NKA的替代品.
- 血液样本在多个时间点收集:基线,治疗前和手术前/后.
- 研究的终点包括残留癌症负担 (RCB) 类,总生存率 (OS) 和无侵袭性疾病生存率 (IDFS).
主要成果:
- 术前低NKA与相对正常NKA (88.1%,p=0.049) 的相比,具有显著较低的无侵袭性疾病的五年生存率 (71.5%).
- 在第五 (p<0.0001) 和第六个治疗周期中,普雷尼索隆的使用显著抑制了血IFNγ水平.
- 不接受普得尼索隆治疗的患者的IFNγ水平显著更高,表明未受损的NKA测量.
结论:
- NKA有可能成为乳腺癌患者的预后生物标志物.
- 这项研究是第一个报告说,普得尼索隆干扰乳腺癌患者的NKA测量.
- 在评估NKA作为生物标志物时,仔细考虑像普得尼索隆这样的并发药物至关重要.
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