COVID-19 劫持宿主表观基因组:机制,生物标志物和长期后果
Alena D Zolotarenko1, Hakob M Poghosyan1, Victoria V Sheptiy1
1Laboratory of Functional Genomics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, Russia.
International journal of molecular sciences
|November 13, 2025
概括
SARS-CoV-2 病毒改变了宿主表观遗传,影响了COVID-19的严重程度和长期COVID. 干细胞的表观遗传变化会产生训练有素的免疫力,这可能解释持续的症状,并提供新的治疗点.
科学领域:
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- COVID-19的发病过程涉及SARS-CoV-2与宿主基因组的相互作用.
- 表观遗传修饰在疾病进展和长期影响中发挥着关键作用,如长期COVID.
研究的目的:
- 审查病毒诱导的表观遗传变化的机制.
- 突出突出各种细胞类型的表观遗传变化,这些变化有助于COVID-19.
- 讨论疾病严重程度和潜在的治疗策略的表观遗传生物标志物.
主要方法:
- 关于COVID-19表观遗传学的当前文献的审查.
- 对宿主表观基因组病毒操纵的分析.
- 检查血液造血干细胞中的表观遗传重编程.
主要成果:
- SARS-CoV-2抑制抗病毒反应,并通过表观遗传操纵促进复制.
- 多种细胞中病毒诱导的表观遗传变化有助于致病的产生.
- 造血干细胞的重编程导致训练有素的免疫力和潜在的长期COVID机制.
- 诸如甲基化特征 (AIM2,HLA-C,PARP9) 和miRNA配置文件等表观遗传生物标志物与疾病严重程度有关.
结论:
- 了解病毒宿主表观遗传学是开发针对COVID-19的向疗法的关键.
- 表观遗传修饰为预测疾病严重程度和结果提供了潜在的生物标志物.
- 向表观遗传改变可能会缓解长期COVID的持续性炎症和症状.
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