乳清蛋白的抗癌潜力-生物活性和功能机制的系统审查
Selin Elmas1, Meliha Fındık2, Ramazan Kıyak2
1Department of Food Engineering, Faculty of Agriculture, Uludag University, Bursa 16059, Turkey.
International journal of molecular sciences
|November 13, 2025
概括
乳清蛋白 (Whey Proteins, WPs) 在癌症治疗中具有支持性的营养特征,有可能抑制瘤生长并改善患者的福祉. 需要进一步的研究来证实在临床环境中益处和最佳使用.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 癌症治疗带来了诸多挑战,包括副作用和营养不良.
- 功能性食品,特别是乳清蛋白 (WPs),正因其潜在的治疗特性而受到越来越多的关注.
- 植物具有抗氧化,免疫调节和抗癌特征.
研究的目的:
- 系统地审查乳清蛋白 (WPs) 对各种癌症类型的影响.
- 评估WP作为癌症患者护理中的支持性营养剂的价值.
- 探索WP对瘤细胞行为和患者结果的影响.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中的系统文献搜索.
- 包括2000年至2024年间发表的24项研究,遵守PRISMA指南.
- 分析临床前 (实验室) 和临床研究数据.
主要成果:
- 乳清蛋白 (Whey Proteins, WPs) 显示出潜在的抗癌作用,包括抑制瘤细胞生长和促进亡.
- WPs调节了免疫活性,并影响了关键的信号通路 (PI3K/Akt,mTOR,Wnt/β-catenin).
- 临床研究表明,WP补充可以改善营养状况,减少化疗副作用,提高生活质量.
结论:
- 乳清蛋白 (WPs) 显示出在癌症治疗中作为耐受性良好的营养剂的巨大潜力.
- 不同形式的WP (缩物,分离物,水解物) 可能会影响疗效.
- 高质量的随机对照试验对于验证发现和指导临床应用至关重要.
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