超炎症在肥胖症的系统性功能障碍中的作用:综合性审查
Ioana-Maria Crasan1, Matei Tanase1, Corina Elena Delia1,2
1Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 5th District, 050095 Bucharest, Romania.
International journal of molecular sciences
|November 13, 2025
概括
肥胖是一种复杂的系统性疾病,而不仅仅是热量问题. 了解其代谢,免疫和表观遗传因素是新疗法的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢科学 代谢科学
- 内分泌学 在内分泌学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 肥胖症被重新定义为一种复杂的系统性疾病,涉及代谢,神经内分泌,免疫和表观遗传失调.
- 脂肪组织是一种动态的内分泌和免疫器官;其扩张驱动慢性炎症 ("转炎"),影响胰岛素信号传递,导致胰岛素抵抗,2型糖尿病和心血管疾病.
- 肠道微生物群失调和表观遗传修饰进一步加剧系统功能障碍,影响下丘脑功能,荷尔蒙抵抗力和生殖健康.
研究的目的:
- 在理解肥胖方面整合分子,神经内分泌和免疫代谢因素.
- 将肥胖重新定义为全身功能障碍的综合表现.
- 倡导转向个性化,多目标的肥胖干预措施的范式转变.
主要方法:
- 审查当前对肥胖的分子,神经内分泌和免疫代谢基础的理解.
- 整合了有关炎症通路 (NF-kB,NLRP3炎症体),免疫细胞透,肠道微生物群和表观遗传修饰的数据.
- 对胰岛素信号传递,代谢内毒性,神经内分泌调节和生殖健康的影响分析.
主要成果:
- 肥胖症涉及慢性,低度炎症 ("元炎症"),由功能障碍的脂肪组织驱动.
- 肠道微生物群失调和表观遗传变化对肥胖的系统性影响有很大贡献.
- 现有研究强调了代谢,免疫和表观遗传轴在肥胖病原发生的相互联系.
结论:
- 肥胖是一种多方面的系统性疾病,需要一个综合的视角超越传统的体重管理.
- 个性化,多目标干预调节免疫代谢网络,微生物群和表观遗传学是必不可少的.
- 解决全球肥胖流行病需要一种转化方法,重点关注这些相互连接的生物系统.
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