呼吸器相关的肺损伤:病理生理学,预防和新兴的治疗策略
Ana Costa1, Bintia Sakho1, Sangel Gomez1
1Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
International journal of molecular sciences
|November 13, 2025
概括
肺部保护性通风可以最大限度地减少与呼吸器相关的肺损伤 (VALI),并提高生存率. 本综述探讨了VALI病理生理学,风险因素和新兴治疗方法,包括人工智能和机器学习,用于预防.
科学领域:
- 关键护理医学 关键护理医学
- 肺部医学 肺部医学
- 生物医学工程 生物医学工程
背景情况:
- 机械通风对于氧化或二氧化碳去除不足的患者至关重要.
- 机械通风可以导致肺部损伤 (卷风创伤,巴罗创伤,心电创伤,生物创伤),并加剧诸如急性呼吸困扰综合征等疾病.
- 呼吸器相关的肺损伤 (VALI) 可以启动系统性炎症,导致多器官衰竭.
研究的目的:
- 审查呼吸器相关肺损伤 (VALI) 的病理生理学,系统性影响和风险因素.
- 讨论临床表现,诊断和当前的保护性通风策略.
- 探索新兴的治疗方法和跨学科的方法来预防VALI.
主要方法:
- 关于VALI的病理生理学,临床方面和治疗策略的综合文献综述.
- 整合跨学科研究,包括细胞和分子反应.
- 检查新的药理学,干细胞,人工智能和机器学习方法.
主要成果:
- 机械通风虽然可以挽救生命,但会造成肺损伤和全身炎症的风险.
- 肺保护性通风策略对于尽量减少VALI和改善患者的治疗结果至关重要.
- 新兴疗法和先进技术为VALI预防提供了新的框架.
结论:
- 了解VALI病理生理学是制定有效的预防和治疗策略的关键.
- 必须采用多学科的方法,将机械考虑与新型治疗方法相结合.
- 未来的方向包括利用人工智能和机器学习进行个性化VALI预防.
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